CHOP
While short-read sequencing is still essential for studying RNA and gene expression, new methods are providing a sharper picture of transcript variants.
Pediatric Brain Tumor Proteomics Highlight Possible Treatment Targets, Biomarkers
An integrated proteogenomic analysis led to previously unappreciated treatment targets or prognostic markers in craniopharyngioma, high-grade glioma, and other tumor types.
In a newly published paper, CHOP researchers described a method for rebuilding patient histories en masse to create gene-specific "footprints" in clinical records.
The tool, developed by Children's Hospital of Philadelphia, was able to establish distinct mutational patterns in five major pediatric cancers.
Human Tumor Atlas Network Team Shares Strategy for Tracking Tumor Transitions
A new paper outlines an upcoming effort to trace tumor development and trajectory in time and space using single-cell genetics and other genomic methods.