Chinese University of Hong Kong

This Week in PNAS

In PNAS this week: whole genome and population genetic analysis of two aspen species, signatures of circulating hepatocellular carcinoma tumor DNA, and more.

Investigators, led by Hong Kong researcher and Grail collaborator Dennis Lo, described a cancer detection strategy using cleavage patterns in circulating DNA molecules.

The NGS-based test improves on a previous PCR-based version and detects circulating DNA from Epstein Barr virus that is shed from cancer cells.

Using Epstein-Barr virus DNA as a marker, investigators uncovered several individuals with early-stage nasopharyngeal cancers in a large screening effort in China.

Cirina will operate as a subsidiary of Grail and the combined entity will collaborate with Dennis Lo's lab at the Chinese University of Hong Kong. 

The approach, which uses 10x Genomics technology for haplotyping, requires neither mutation-specific assays nor DNA from affected family members.

The joint center will, among other things, design, establish, and conduct training in clinical genetics and genetic counseling tailored to key Asian regions.

Researchers used bisulfite sequencing to identify methylation markers in order to trace circulating DNA fragments back to their tissue of origin. 

The researchers sequenced plasma samples on the MinIon and found that NIPT could be feasible with improvements to accuracy, DNA extraction, and library prep.

NEW YORK (GenomeWeb) – A Chinese team led by Chinese University of Hong Kong researcher and Sequenom advisor Dennis Lo has demonstrated the feasibility of using RNA sequencing to profile fetal and maternal RNA transcripts in maternal blood.

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The Washington Post reports on a Federal Bureau of Investigation plan to place rapid DNA analyzers at booking stations around the country.

In an editorial, officials from scientific societies in the US and China call for the international community to develop criteria and standards for human germline editing.

The US National Institutes of Health is to review studies that have received private support for conflicts of interest, according to the New York Times.

In Science this week: the PsychENCODE Consortium reports on the molecular mechanisms of neuropsychiatric disorders, and more.