Chinese University of Hong Kong
Bionano is bolstering its presence in China with the desire to eventually seek NMPA approval for its Saphyr optical genome mapping platform.
A new study has explored patterns in these molecules in pregnant women, showing potential for detection of fetal monogenic diseases and pregnancy complications.
Children With Autism May Have Underdeveloped Gut Microbiomes, Metagenomic Analysis Finds
The researchers are now developing a PCR-based diagnostic tool to evaluate the markers they found in a larger, independent cohort and across different populations.
The approach considers kinetic signals from the DNA polymerase used in PacBio sequencing, as well as the sequence context, to determine cytosine methylation sites.
The method, called jagged end analysis by sequencing and developed by a team in Hong Kong, relies on DNA end repair with methylated or unmethylated cytosine.