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Although the developers note that the protocol particularly benefits the sequencing of AT-rich genomes, they say that it is also quicker than the standard method, which requires PCR amplification, and "should be used routinely to prepare libraries for Genome Analyzer sequencing."

Using gene expression and copy number analyses of dozens of endometrial cancers, an international research team has turned up characteristic expression profiles and gene amplifications linked to poor outcomes.

Complete Genomics will use its DNA sequencing technology to sequence five samples provided by the Broad Institute.

Short Reads: Mar 3, 2009

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Febit, Complete Genomics, Broad Institute, EnGenCore, German Genetics Society, Albert Einstein College of Medicine, CLC Bio, Boehringer Ingelheim, Genomatix

Direct-to-consumer genetic testing companies have based their products on what scientists have accomplished, but the caveat is that the science is still in its early days.

The company claims that compared to other targeted sequence-enrichment methods, its approach leads to more uniform coverage, or less enrichment bias. RainDance said it plans to offer up to 4,000 amplifications in a single tube later this year.

Both companies are offering users of second-generation sequencing systems new tools to select portions of the genome for targeted resequencing but have optimized their products for different sequencing platforms.

Planned improvements for the SOLiD include a sample prep-automation instrument that is expected to be market-ready towards the end of 2009. Life Tech expects its Genetic Systems unit, home to the CE and SOLiD platforms, to grow in "low single digits" this year.

The company continues to develop longer reads for its Genome Sequencer FLX system and to improve its sample-prep process, add more multiplex identifying tags, and add new paired-end library protocols.

At the Advances in Genome Biology and Technology conference this week, the company also presented its first human genome sequencing data.

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A Minnesota toddler given a gene therapy to treat her spinal muscular atrophy is now walking, according to Newsweek.

NBC Bay Area reports a California lab has been certified to conduct forensic mitochondrial DNA sequencing.

The New York Times reports on how environmental DNA sampling could monitor endangered species.

In Cell this week: proteomic, genomic, and transcriptomic analysis of endometrial cancer; deep neural network learning-based approach to antibiotic discovery; and more.