The team evaluated various technologies in an attempt to develop a framework to compare future methods against and to serve as a guide for researchers.
The researchers used circularly permuted Cas9 variants to produce four cytosine and four adenine base editors with an expanded editing window.
With DNA methylation data for more than 1,800 chronic lymphocytic leukemia B cells, researchers tracked CLL epimutation rates and saw lineages with distinct treatment responses.
Following an April hackathon and work from Melbourne Genomics and Fred Hutch, the Broad is about to release a long-awaited AWS version of its Cromwell workflow engine.
To solve the problem, the researchers developed new variants of the editors that still edit DNA efficiently but have significantly lower RNA editing activity.
As CRISPR technology continues to progress, some researchers are turning their focus to discovering or developing countermeasures and controls.
Researchers used the platform to identify small synthetic molecules that disrupt the editing activity of the SpCas9 nuclease.
In PNAS this week: core Pseudomonas aeruginosa genome, study of ancient Paget's disease of the bone, and more.
The company launched last month with initial financing of $35 million and licenses to CRISPR and synthetic biology technology from the Broad and Harvard.
In a study of more than 300,000 participants, middle-aged individuals with a high polygenic score weighed nearly 30 pounds more on average than those with lower scores.
The New York City Police Department will be removing DNA profiles from a local database if they are from people who were never convicted of a crime, the New York Times reports.
Science reports that accusations of sexual assault against a microbiome researcher has also led to questions about his academic certifications.
Wired reports that researchers are analyzing the DNA fish leave behind in water to study their populations.
In Science this week: comprehensive cellular map of the human thymus, evidence of admixture between the ancestors of Neanderthals and Denisovan and a 'superarchaic' population.