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Broad Institute

The activity of the ABE8e editor is increased 590-fold compared to the activity of the ABE7.10, and it can be paired with a variety of Cas9 or Cas12 homologs. 

In a new study, using larger numbers of patient-specific mutations helped better detect residual disease in breast cancer patients' blood after treatment.

A genetic analysis based on more than 32,000 individuals living in the US traced the ancestry, historical migration, and other patterns present in populations around the country.

Researchers sequenced about 200 mumps cases from Massachusetts and elsewhere to understand how the virus spread locally and more broadly in 2016 and 2017.

The EPO rejected arguments that were filed in opposition to the patent, which covers the use of CRISPR-Cas9 in cellular and non-cellular settings.

In Cell this week: a quantitative proteomic atlas based on the Cancer Cell Line Encyclopedia, gene regulation and differentiation in Toxoplasma gondii, and more.

Exome sequences for nearly 35,600 cases and controls revealed genes prone to mutation in autism spectrum disorder, along with related cell types, functions, and developmental stages.

The genomes of four children who died in Cameroon 3,000 to 8,000 years ago pointed to diverse early lineages and helped tease out historical population relationships.

The European Patent Office appeals board upheld the decision made by the EPO after its initial review in 2018.

Illumina, Twist Bioscience, and DNA Script are among the private sector collaborators of the groups receiving funds to develop technology platforms.

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NPR reports that graduate students in the US are helping with SARS-CoV-2 testing.

Politico reports President Donald Trump has signed the $2 trillion coronavirus relief package.

A new analysis finds that peer review improves the quality of preprints just a little bit, according to ScienceInsider.

In PLOS this week: epigenetic drug triggers anti-viral activity, viral diversity among individuals with HIV experiencing virological failure, and more.