Broad Institute

This Week in Science

In Science this week: CRISPR-based approach for recording cellular events, and more.

An analysis of metagenomic sequences from donor and recipient stool samples highlighted bacterial abundance, phylogeny, and strain features influencing engraftment.

The Broad Institute also announced announced a setback in proceedings over a CRISPR patent application filed in Europe.

The new, open-source GATK4 widens its coverage and compatibility with major cloud platforms while adding machine learning.

Teams studying kidney and skin cancers independently implicated SWI/SNF chromatin remodeling mutations in checkpoint blockade immunotherapy response.

The most significant update to the Connectivity Map since its 2006 founding offers a low-cost way to analyze most RNA transcriptomes.

This Week in Cell

In Cell this week: collection of breast cancer organoid lines, study of bacterial symbiont of beetles, and more.

This Week in PLOS

In PLOS this week: HIV-1 genetic diversity in Bangalore; gene variants and noise-induced hearing loss; and more.

The Danish informatics firm is exploring analytical tools for its InWeb_InBioMap network, which currently contains more than 700,000 protein-protein interactions. 

The creator of the Genome Aggregation Database sees an ever-expanding GnomAD database as a centerpiece to improving the diagnosis of rare diseases.

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The New York City medical examiner is overseeing an effort to identify missing persons using DNA, according to the Associated Press.

Nobel laureate Günter Blobel has died at 81, the New York Times reports.

In PNAS this week: mouse model of genetically induced emphysema, gene expression signatures of circulating melanoma cells, and more.

Technology Review reports that 2017 was the year of consumer genetic testing and that it could spur new analysis companies.