The researchers used circularly permuted Cas9 variants to produce four cytosine and four adenine base editors with an expanded editing window.
With DNA methylation data for more than 1,800 chronic lymphocytic leukemia B cells, researchers tracked CLL epimutation rates and saw lineages with distinct treatment responses.
Following an April hackathon and work from Melbourne Genomics and Fred Hutch, the Broad is about to release a long-awaited AWS version of its Cromwell workflow engine.
To solve the problem, the researchers developed new variants of the editors that still edit DNA efficiently but have significantly lower RNA editing activity.
As CRISPR technology continues to progress, some researchers are turning their focus to discovering or developing countermeasures and controls.
Researchers used the platform to identify small synthetic molecules that disrupt the editing activity of the SpCas9 nuclease.
In PNAS this week: core Pseudomonas aeruginosa genome, study of ancient Paget's disease of the bone, and more.
The company launched last month with initial financing of $35 million and licenses to CRISPR and synthetic biology technology from the Broad and Harvard.
In a study of more than 300,000 participants, middle-aged individuals with a high polygenic score weighed nearly 30 pounds more on average than those with lower scores.
Common non-coding variants, along with rarer coding alterations, appear to contribute to a developmental disease with bowel and other gastrointestinal symptoms.
University of Idaho researchers model the scientific discovery process to examine the link between reproducibility and scientific truth.
A bill passed by a US House of Representatives appropriations subcommittee would give scientific agencies including the National Science Foundation boosts in funding.
Relocating USDA agencies outside of Washington, DC, may make them less effective, critics of the move tell NPR.
In PLOS this week: genes that help Borrelia burgdorferi survive in ticks, CiliaCarta collection of about 1,000 suspected cilia genes, and more.