Broad Institute In Brief This Week: MDxHealth, Agilent Technologies, IsoPlexis, IntegraGen, More News items for the week of Jan. 9, 2023. Study Traces Maternal Impacts on Developing Infant Gut Microbe, Metabolite Features Researchers identified horizontal gene transfer between maternal and infant microbiomes, as well as other factors contributing to infant gut microbiome development. Computational Tool Tracks Genetic Variation Effects of Off-Target Gene Editing Researchers came up with a strategy for predicting off-target edits related to genetic variation, using it to assess off-target variant effects on a potentially therapeutic guide RNA. Ashkenazi Jewish Population History Revealed With Ancient DNA Analysis Along with evidence of an earlier founder event, samples from a 14th century German cemetery revealed ties between ancient and modern-day Ashkenazi Jewish populations. Complex Trait-Related CNVs Unearthed Using Haplotype-Informed Approach Researchers tracked down 269 associations between complex traits and copy number variants uncovered with the help of haplotype-informed copy number variation analyses. Oct 25, 2022 Diabetes Polygenic Risk Score Performance Improved by Addition of Rare Variants Oct 24, 2022 Autism-Linked Variants at Chromosome 16p Influence Nearby Gene Expression Oct 13, 2022 St. Jude, Broad Institute, Dana-Farber Partner to Advance Pediatric Cancer Research Sep 29, 2022 Integration of Single-Cell RNA-seq, Genomic Data Reveals Cell Types Involved in Genetic Diseases Sep 22, 2022 Allen Institute Launches $173M NIH-Funded Coalition to Create Human, Primate Brain Cell Atlases Premium Sep 22, 2022 NIH Launches $500M Effort to Map Cells of the Human Brain Sep 20, 2022 Nvidia, Broad Institute Team on Deep Learning, Natural Language Processing in GATK Sep 15, 2022 Broad Institute Study Evaluates Ultima Genomics Sequencer for Single-Cell RNA-Seq Premium Sep 12, 2022 Broad Institute, Datavant Strike Health Data Alliance Aug 18, 2022 Autism Spectrum Disorder Studies Uncover Additional Genetic Risk Variants Aug 17, 2022 Schizophrenia Study Implicates Ultrarare Variants in Cognitive Features Aug 15, 2022 Phenotype Ties to Rare Variants Systematically Unearthed in UK Biobank Exomes Aug 12, 2022 Heart Dysfunction Insights Drawn From Age-Related Cardiomyocyte Mutations Aug 5, 2022 Chronic Lymphocytic Leukemia Genomic Study Reveals New Subtypes, Ties to Outcomes Aug 3, 2022 Long-Read Sequencing Reveals Tens of Thousands of Novel Transcripts Across Different Human Tissues Premium Aug 3, 2022 New COVID-19 Genetic Risk Loci Discovered in Cross-Ancestry GWAS Meta-Analysis Jul 27, 2022 Researchers Develop Map of Protein-Coding Genes Sensitive to Dosage Changes Jul 13, 2022 Family History Improves Polygenic Risk Scores for Complex Disease in Non-Europeans Jul 6, 2022 Structural Variant Study Points to Pediatric Glioma Drivers, Prognostic Features Jun 27, 2022 Native Peruvian Genetic Ancestry Linked to Increased Risk of Tuberculosis Progression Load More Breaking News Cancer Prognoses Informed by Module-Based Approach, Study Finds People in the News at Illumina, Centogene, BioSkryb New Products Posted to GenomeWeb: Bio-Rad, BD, Analytik Jena, BioMérieux Genetic Technologies to Raise A$5M in Direct Stock Offering In Brief This Week: SD Biosensors, Meridian, Oncocyte, Opko Health, GeneDx, More The Scan Study Reveals New Details About Genetics of Major Cause of Female Infertility Researchers in Nature Medicine conducted a whole-exome sequencing study of mote than a thousand patients with premature ovarian insufficiency. Circulating Tumor DNA Shows Potential as Biomarker in Rare Childhood Cancer A study in the Journal of Clinical Oncology has found that circulating tumor DNA levels in rhabdomyosarcoma may serve as a biomarker for prognosis. Study Recommends Cancer Screening for Dogs Beginning Age Seven, Depending on Breed PetDx researchers report in PLOS One that annual cancer screening for dogs should begin by age seven. White-Tailed Deer Harbor SARS-CoV-2 Variants No Longer Infecting Humans, Study Finds A new study in PNAS has found that white-tailed deer could act as a reservoir of SARS-CoV-2 variants no longer found among humans.