Brigham and Women's Hospital
Parkinson's Disease Progression Linked to Five Variants in Genome-Wide Survival Study
The researchers also developed a polygenic hazard score to predict which individuals with Parkinson's are likely to develop disease-related dementia.
Renal Cell Carcinoma Risk Gene Representation Can Vary With Ancestry
While risky variants in the FH gene were more common in renal cell carcinoma patients with African ancestry, European patients more often carried pathogenic CHEK2 gene changes.
Dana Farber Team Applies PCR Method to ID Microsatellite Instability in Tumor-Derived Samples
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The group aims to adapt the method, which detects poly-adenine tails, to monitor for minimal residual disease in late-stage colon cancer patients after surgery.
Disease-Linked Mutations May Affect Protein-Protein Interactions, Influence Drug Response
Both germline variants and somatic tumor variants linked to disease are more likely to disrupt protein-protein interactions than other variants.
Genetic Risk of Cognitive Decline Varies Between Latino Populations, Study Finds
The APOE-ε4 allele, a major genetic risk factor for Alzheimer's disease, conveys more risk among Cuban than other Latino populations, the analysis found.