The approach generates a gRNA against a common genetic element called the flippase recognition target, making genome editing faster and scarless in E. coli.
Baylor College of Medicine's Olga Dudchenko sad the approach could assemble de novo mammalian genomes for less than $1,000.
Researchers detected excess genetic risk and/or misclassification when profiling ClinVar variants in ACMG-59 and OrphaNet genes using genome and exome sequences.
In Cell this week: sequencing to understand medulloblastoma metastases, genome and transcriptome implicates TAP1 in X-linked Dystonia-Parkinsonism, and more.
In Genome Research this week: long-read Caenorhabditis elegans sequences, enhancer patterns in breast cancer cell lines, and more.
A Baylor study compared 25 algorithms in terms of their ability to characterize missense variants and found significant disagreement in their predictions.
In Genome Biology this week: new hot pepper reference genomes, comparison of variant classification algorithms, and more.
CEO Anders Rylander said the company will initially market its DiviTum assay for breast cancer cases, though it could be used to monitor cell proliferation in all cancer types.
In PNAS this week: three-dimensional chromosome structure, ovarian cancer immunopeptidome, and more.
A new consensus report suggests RB1 testing and genetic counseling to stratify risk and guide ophthalmic screening in kids with affected family members.
Lawmakers have asked four direct-to-consumer genetic testing companies to explain their privacy policies and security measures, according to Stat News.
The Trump Administration has proposed a plan to reorganize the federal government, the Washington Post reports.
In Science this week: genetic overlap among many psychiatric disorders, and more.
The Economist writes that an increasing number of scientific journals don't do peer review.