ADNI

NEW YORK (GenomeWeb) – Proteomics firm Caprion this week launched its CNS ProteoCarta panel for the study of central nervous system diseases.

NEW YORK (GenomeWeb News) – Common genetic variants at three newly detected loci appear to be linked to elevated Alzheimer's disease risk, according to a study out today in the journal Neuron.

According to a team led by researchers at Plymouth University, there are significant flaws in the standard cognitive test used to diagnose and evaluate Alzheimer's disease patients, which could be hampering efforts to develop treatments and biomarkers for the disease.

A consortium of researchers working as part of the Alzheimer's Disease Neuroimaging Initiative has completed an analysis of potential plasma protein biomarkers for Alzheimer's in three separate patient cohorts, identifying four analytes associated with the disease.

By Adam Bonislawski
Researchers at Australia's University of Newcastle have published one of the first analyses of data from the Alzheimer's Disease Neuroimaging Initiative's plasma proteome project.

The figure comes from a report commissioned by proteomics firm Proteome Sciences, which, like a number of other protein biomarker firms including Quanterix, Rules-Based Medicine, and NextGen Sciences, has made AD a significant focus of its R&D and commercialization efforts.

The new guidelines mark the second publication in recent months to suggest that protein biomarkers be integrated into current definitions of Alzheimer's disease, though the new proposal explicitly calls for protein biomarkers to be used only in research settings.

Their findings suggest that acetylated tau might be a useful addition to more established AD biomarkers like amyloid-beta, tau, and phosphorylated tau and could help clinicians distinguish between various forms of frontotemporal lobar degeneration.

The diagnostic is being developed using a new peptoid-based technique for detecting disease-specific antibodies that could prove broadly useful as a protein biomarker discovery tool, said a researcher.

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Senator Elizabeth Warren (D-Mass.) has released the results of a genetic ancestry analysis, the Boston Globe reports.

Retraction Watch's Ivan Oransky and Adam Marcus report that Harvard Medical School and Brigham and Women's Hospital have recommended that more than 30 papers from a former researcher be retracted.

Thomas Steitz, who won the 2009 chemistry Nobel Prize for his ribosome work, has died, the Washington Post reports.

In PLOS this week: mechanisms for genes implicated in coronary artery disease, rumen microbes and host genetics influence cow methane production, and more.