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In a profile of Johns Hopkins University's Bert Vogelstein in Science, Jocelyn Kaiser says he and his co-PI Kenneth Kinzler have helped "lay the foundation of cancer genetics," work that now inspires other researchers to use genetics to predict cancer risk and develop personalized treatments. And yet, Kaiser adds, Vogelstein and Kinzler seem to spend most of their time these days being skeptical about these efforts. "Vogelstein seems to enjoy pricking balloons.

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In Nature this week: factors affecting the success of whole-genome sequencing for routine clinical diagnosis, and more.

A large meta-analysis from an international team reports that nature and nurture have about an equal overall influence on human traits.

The Lasker Foundation's Claire Pomeroy laments the state of NIH funding at Forbes.

Social media is changing how scientists discuss research, as tweets from University of Chicago's Yoav Gilad about a Mouse ENCODE paper have shown, Nature reports.