NEW YORK (GenomeWeb News) – The National Institutes of Health expects to use $4 million over the next year to fund research to speed up development of next-generation tools for distinguishing heterogeneous states among cells in situ and enhancing their sensitivity, selectivity, scalability, and other measures.
The grants are funded under the NIH Office of the Director's Single Cell Analysis Program (SCAP), which aims to support studies to understand cell heterogeneity, tissue function, and the emergence of diseases in order to change how cells are characterized and to develop new personalized medicine tools.
These grants will provide up to $275,000 for two years to between eight and 12 investigators seeking to perform early-stage, high-risk, and high-impact studies.
These projects should focus on tool development, but also may test tools in the context of heterogeneous systems, such as projects to elucidate molecular systems and how they affect genomic stability and evolution, characterize heterogeneous cell responses to environmental changes, identify transitions in cellular states, and a range of other studies.
Applicants for these exploratory/developmental research grants may propose development of tools to perform global functional analyses of cell types, for multiplex analysis or manipulation of single cells, automated and scalable assays for high-throughput analysis of single cells in situ, and systems-level single-cell dataset analyses or modeling in the context of tissues or whole organisms, among other efforts.