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Waters SARS-CoV-2 LC-MS Kit

Waters has launched the research-use-only SARS-CoV-2 LC-MS Kit, which uses an orthogonal analytical method to directly detect and quantify SARs-CoV-2 Nucleocapsid peptides. According to the company, testing has shown that researchers can achieve the analytical sensitivity required to detect and quantify low levels of three unique peptides derived from the SARS-CoV-2 NCAP protein, with data on the Xevo TQ-XS System showing a lower limit of quantitation of 3 amol/µL. Waters said this is made possible by using an anti-peptide antibody enrichment sample prep method and antibodies from SISCAPA Assay Technologies. Results can be captured with clean, low-noise chromatograms in less than two minutes per sample, Waters added. The kit has been optimized on both the Xevo system and the Acquity I-Class Plus System, the company said.

The Scan

Cancer Survival Linked to Mutational Burden in Pan-Cancer Analysis

A pan-cancer paper appearing in JCO Precision Oncology suggests tumor mutation patterns provide clues for predicting cancer survival that are independent of other prognostic factors.

Australian Survey Points to Public Support for Genetic Risk Disclosure in Relatives of At-Risk Individuals

A survey in the European Journal of Human Genetics suggests most adult Australians are in favor of finding out if a relative tests positive for a medically actionable genetic variant.

Study Links Evolution of Stony Coral Skeleton to Bicarbonate Transporter Gene

A PNAS paper focuses on a skeleton-related bicarbonate transporter gene introduced to stony coral ancestors by tandem duplication.

Hormone-Based Gene Therapy to Sterilize Domestic Cat

A new paper in Nature Communication suggests that gene therapy could be a safer alternative to spaying domestic cats.