Twist Bioscience TCR and CAR Libraries

Twist Bioscience has launched the Twist T-cell Receptor (TCR) and chimeric antigen receptor (CAR) libraries to enable researchers to rapidly create custom libraries to identify and develop next-generation cell therapies. These large and diverse libraries are made of up to 10,000 gene fragment combinations, enabling high-throughput screening and characterization of novel and known sequence variants for therapeutic discovery, Twist said. In these libraries, combinations of custom gene parts are shuffled to allow customers to test multiple elements at once, explore new combinations of variable binding regions, and select candidates with the greatest therapeutic potential, accelerating the discovery phase and expediting the timeline to the clinic, the company said.