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Twist Bioscience Human Methylome Panel

Twist Bioscience has launched its human methylome panel, a target enrichment assay for next-generation sequencing. The 123-Mb panel uses hybrid capture to detect the most recently identified and relevant CpG methylation regions in the genome, covering 84 percent of CpG island sites. It achieves depth of coverage of 90 percent of bases at 30x coverage with 95 percent on-target rate for probes as well as high uniformity across target regions.

The Scan

Machine Learning Helps ID Molecular Mechanisms of Pancreatic Islet Beta Cell Subtypes in Type 2 Diabetes

The approach helps overcome limitations of previous studies that had investigated the molecular mechanisms of pancreatic islet beta cells, the authors write in their Nature Genetics paper.

Culture-Based Methods, Shotgun Sequencing Reveal Transmission of Bifidobacterium Strains From Mothers to Infants

In a Nature Communications study, culture-based approaches along with shotgun sequencing give a better picture of the microbial strains transmitted from mothers to infants.

Microbial Communities Can Help Trees Adapt to Changing Climates

Tree seedlings that were inoculated with microbes from dry, warm, or cold sites could better survive drought, heat, and cold stress, according to a study in Science.

A Combination of Genetics and Environment Causes Cleft Lip

In a study published in Nature Communications, researchers investigate what combination of genetic and environmental factors come into play to cause cleft lip/palate.