Tempus Loop

Tempus AI has launched Tempus Loop, an oncology-focused platform for target discovery and validation that integrates real-world patient data with human-derived biological models and CRISPR-screens. The platform uses artificial intelligence to uncover insights for preclinical therapeutic development and utilizes the real-world data to identify patient subpopulations with similar clinical, pathologic, and molecular patterns. It then uses systems biological approaches to determine novel target genes and multimodal signatures, which can then be used to map patient subcohorts to relevant patient-derived organoids. It can then validate targets using high-throughput functional screens. The firm has deployed Loop to prioritize drug targets in patient subpopulations with severe unmet needs for a large pharmaceutical company, it said.