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Roche Avenio Tumor Tissue Comprehensive Genomic Profiling Kit

Roche has launched its Avenio Tumor Tissue Comprehensive Genomic Profiling (CGP) Kit for research use. The jointly developed project from Roche and Foundation Medicine delivers information about complex genomic signatures, including tumor mutational burden, microsatellite instability, and loss of heterozygosity, in addition to a comprehensive genomic panel. It provides an end-to-end next-generation sequencing workflow including DNA extraction and library preparation, and delivers results by the FoundationOne Analysis Platform via Avenio Connect.

The kit's gene panel is drawn from the FoundationOne companion diagnostic panel, analyzing 324 cancer-related genes across four main classes of genomic alterations and genomic signatures. It is configured to run 24 samples with results in five days on Illumina's NextSeq 500/550 RUO and NextSeq 550 Dx System in research mode.

The kit is intended for laboratories to use in house and will launch in Europe, North America, Asia, and South America.

The Scan

Call for a Different Tack

Experts weigh the value of recent experiments testing genetically modified pig kidneys using brain-dead individuals, according to Nature News.

Wastewater Warning

The New York Times reports that wastewater surveillance in some parts of the US point to a possible surge.

Can't Get in the Program

Due to the Northern Ireland protocol dispute, the European Union is preventing UK researchers from joining the Horizon Europe research program, the Times of London reports.

Science Paper on Spatial-Controlled Genome Editing

In Science this week: approach to enable a CRISPR-Cas13a-based system to be used as a cancer therapy.