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Primordial Genetics RNA Polymerases

Synthetic biology firm Primordial Genetics has launched proprietary RNA polymerases, called Prima RNApols, for the generation of mRNA-based vaccines and therapeutics. According to the company, the new polymerases produce mRNA with higher yields, better purity, and lower double-stranded RNA levels than standard T7 RNA polymerase. They are available to customers for three-month evaluation trials, and Primordial Genetics is offering both exclusive and non-exclusive license options.

The Scan

Sick Newborns Selected for WGS With Automated Pipeline

Researchers successfully prioritized infants with potential Mendelian conditions for whole-genome sequencing or rapid whole-genome sequencing, as they report in Genome Medicine.

Acne-Linked Loci Found Through GWAS Meta-Analysis

Researchers in the European Journal of Human Genetics find new and known acne vulgaris risk loci with a genome-wide association study and meta-analysis, highlighting hair follicle- and metabolic disease-related genes.

Retina Cell Loss Reversed by Prime Editing in Mouse Model of Retinitis Pigmentosa

A team from China turns to prime editing to correct a retinitis pigmentosa-causing mutation in the PDE6b gene in a mouse model of the progressive photoreceptor loss condition in the Journal of Experimental Medicine.

CRISPR Screens Reveal Heart Attack-Linked Gene

Researchers in PLOS Genetics have used CRISPR screens to home in on variants associated with coronary artery disease that affect vascular endothelial function.