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Pacific Biosciences Multiplexed Arrays Sequencing

Pacific Biosciences has launched a new kit for single-cell transcriptome sequencing. Multiplexed Arrays Sequencing (MAS-Seq), developed in partnership with the Broad Institute and 10x Genomics, supports single-cell gene expression and RNA isoform research. MAS-Seq will help single-cell researchers better identify and characterize novel isoforms, novel driver mutations, and cancer fusion genes, PacBio said. Accompanying the kit is new SMRTLink software to support single-cell transcriptome analysis.

The Scan

Open Pediatric Brain Tumor Atlas Team Introduces Genomic Data Collection, Analytical Tools

A study in Cell Genomics outlines open-source methods being used to analyze and translate whole-genome, exome, and RNA sequence data from the Pediatric Brain Tumor Atlas.

Neurological Outcomes Linked to Innate Immune Features After Cardiac Arrest

Researchers reporting in Med dig into immune features found a few hours after cardiac arrest that correspond with neurological outcomes.

Mouse Study Finds Circadian Rhythm-Related Gene Expression Changes Linked to Sleep Apnea

A paper in PLOS Biology reveals tissue-specific circadian rhythm and gene expression patterns in an intermittent hypoxia-based mouse model of obstructive sleep apnea.

Polygenic Risk Score to Predict Preeclampsia, Gestational Hypertension in Pregnant Women

Researchers in Nature Medicine provide new mechanistic insights into the development of hypertensive disorders of pregnancy, which may help develop therapeutics.