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New England Biolabs NEBNext Immune Sequencing Kits

New England Biolabs has launched the NEBNext Immune Sequencing Kits, designed for sequencing full-length immune gene repertoires of B and T cells. The kits enable somatic mutation profiling of these cells via the expression of complete antibody chains. They include modular primer sets for the complete V, D, and J segments; full isotype information analysis covering IgM, IgD, IgG, IgA, and IgE; and TCR chain characterization. They also include a bioinformatic workflow using the Galaxy platform, based on the open-source pRESTO toolkit. Users may convert PCR copies derived from individual molecules into consensus sequences via template-switching Unique Molecular Identifier-based mRNA barcoding.

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.