MRC Holland D007 Acute Lymphoblastic Leukemia Assay Update

MRC Holland has launched an updated version of its D007 Acute Lymphoblastic Leukemia (ALL) assay. It relies on SALSA digitalMLPA technology, which combines multiplex ligation-dependent probe amplification with next-generation sequencing and enables the simultaneous quantification of hundreds of genomic targets. The assay offers high-resolution coverage of 73 ALL-related genes and eight regions, copy number detection with 250 probes across the genome, high dynamic range for detecting copy number alterations, and a turnaround time of 48 to 72 hours, with 20 ng DNA input per reaction. The new version features additional probes to increase the coverage of ALL-relevant regions and to target genes of emerging interest for ALL.