Logo

Menarini Silicon Biosystems CellSearch DLL3 RUO Assay

Jul 13, 2023

Menarini Silicon Biosystems has launched a new research-use-only CellSearch lab service to detect expression of the Delta-Like Ligand 3 protein in tumor cells circulating in the bloodstream. According to the company, DLL3 overexpression is associated with the formation of high-grade neuroendocrine tumor types such as small-cell lung cancer. The biomarker tends to be highly expressed in tumor tissue but minimally in normal tissue. Menarini said this is the first time its CellSearch platform is being made available for biopharma companies developing treatments for lung cancer and other neuroendocrine neoplasms.

Breaking News
The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.