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Lexogen RiboCop rRNA Depletion Kit for Yeast

Lexogen has released its RiboCop rRNA Depletion Kit for Yeast. Total RNA is composed of large amounts of undesired ribosomal RNA (rRNA), which accounts for up to 95 percent of all transcripts in an RNA sample, Lexogen said. The RiboCop rRNA Depletion Kit for Yeast enables efficient removal of this rRNA so that equencing reads are focused to RNA of interest, which allows more samples to be multiplexed and significantly reduces the sequencing cost per sample, the company said. RiboCop's rRNA depletion technology is based on hybridization of rRNA to specifically designed oligos and removal with magnetic beads. Lexogen has also developed an algorithm to design specific probe mixes for maximum rRNA removal while keeping unwanted off-target effects at a minimum and preserving unbiased expression profiles. RiboCop is compatible with CORALL RNA-Seq V2 and all standard RNA-Seq library preparation protocols, the company said.

The Scan

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The approach helps overcome limitations of previous studies that had investigated the molecular mechanisms of pancreatic islet beta cells, the authors write in their Nature Genetics paper.

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Tree seedlings that were inoculated with microbes from dry, warm, or cold sites could better survive drought, heat, and cold stress, according to a study in Science.

A Combination of Genetics and Environment Causes Cleft Lip

In a study published in Nature Communications, researchers investigate what combination of genetic and environmental factors come into play to cause cleft lip/palate.