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Integrated DNA Technologies: Alt-R HDR Donor Blocks

Integrated DNA Technologies (IDT) has released Alt-R HDR Donor Blocks for increasing homology-directed repair (HDR) rates in large fragment knock-in experiments. The blocks use chemical modifications to increase HDR rates of large genomic changes and insertions and reduce the occurrence of non-homologous integration of the donor sequence. They are available in lengths ranging from 201 bases to 3,000 bases and are generated from clonally purified DNA.