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Foundation Medicine FoundationOneRNA

Foundation Medicine has launched a new research use and investigational use version of FoundationOneRNA, a tissue-based RNA sequencing test that detects fusions in 318 genes. The company said it uses an extraction method whereby DNA and RNA can be isolated from a single formalin-fixed paraffin-embedded sample to minimize sample volume requirements and help researchers preserve limited tissue samples in clinical studies. The assay also has expanded capabilities to offer gene expression reporting of over 1,500 genes to support biomarker discovery. Foundation Medicine said it is developing a clinical-use version of the test with an anticipated launch in 2024.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.