Dovetail Genomics LinkPrep NGS

Dovetail Genomics has launched its new LinkPrep NGS technology, a chromosome conformation assay which captures genetic variation in the context of the 3D genome, enabling simultaneous genetic and epigenetic data analyses.

LinkPrep offers higher sensitivity in detecting translocations and intrachromosomal rearrangements compared to conventional methods, while also identifying SNVs, insertions, and deletions. LinkPrep captures chromosome-scale haplotype linkage, enabling applications such as allele-resolved copy number variation, haplotype resolution of variant co-occurrence, and karyotype reconstruction in the context of a cancer genome. It is compatible with hybrid capture panels, offering improved sensitivity over whole genome approaches.