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Codex DNA Full-Length SARS-CoV-2 Synthetic Genome

Codex DNA has released a full-length synthetic genome of SARS-CoV-2 for the highly mutated and contagious Omicron variant (B.1.1.529 lineage). The genome was built with the company's BioXp 3250 fully automated synthetic biology benchtop workstation for rapid, accurate, and reproducible writing of DNA and mRNA. With the Omicron variant, Codex DNA offers a full catalogue of 14 SARS-CoV-2 synthetic genomes as well as custom-made SARS-CoV-2 genomes to support researchers. The genomes are available to researchers who pass a rigorous biosecurity screening process to ensure their responsible use, the company noted.

The Scan

RNA Editing in Octopuses Seems to Help Acclimation to Shifts in Water Temperature

A paper in Cell reports that octopuses use RNA editing to help them adjust to different water temperatures.

Topical Compound to Block EGFR Inhibitors May Ease Skin Toxicities, Study Finds

A topical treatment described in Science Translational Medicine may limit skin toxicities seen with EGFR inhibitor therapy.

Dozen Genetic Loci Linked to Preeclampsia Risk in New GWAS

An analysis of genome-wide association study data in JAMA Cardiology finds genetic loci linked to preeclampsia that have ties to blood pressure.

Cancer Survival Linked to Mutational Burden in Pan-Cancer Analysis

A pan-cancer paper appearing in JCO Precision Oncology suggests tumor mutation patterns provide clues for predicting cancer survival that are independent of other prognostic factors.