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Centogene FilterTool Application

CentoGene has launched FilterTool, a web-based application for genetic data interpretation that integrates with the firm's CE-marked CentoCloud software-as-a-service bioinformatics pipeline. FilterTool allows users to display, filter, select, and classify relevant genetic variants identified by next-generation sequencing data analysis. It makes use of Centogene's bio-databank of about 700,000 individuals from 120 countries, which includes more than 2,500 rare and neurodegenerative diseases. The filters are based on curated annotations from Centogene, proprietary prioritization ranks and scores, and guidelines from the American College of Medical Genetics and Genomics. According to the company, FilterTool is one of the first CE-marked, In Vitro Diagnostic Regulation (IVDR) filtering applications for genomic diagnostics.

The Scan

Machine Learning Helps ID Molecular Mechanisms of Pancreatic Islet Beta Cell Subtypes in Type 2 Diabetes

The approach helps overcome limitations of previous studies that had investigated the molecular mechanisms of pancreatic islet beta cells, the authors write in their Nature Genetics paper.

Culture-Based Methods, Shotgun Sequencing Reveal Transmission of Bifidobacterium Strains From Mothers to Infants

In a Nature Communications study, culture-based approaches along with shotgun sequencing give a better picture of the microbial strains transmitted from mothers to infants.

Microbial Communities Can Help Trees Adapt to Changing Climates

Tree seedlings that were inoculated with microbes from dry, warm, or cold sites could better survive drought, heat, and cold stress, according to a study in Science.

A Combination of Genetics and Environment Causes Cleft Lip

In a study published in Nature Communications, researchers investigate what combination of genetic and environmental factors come into play to cause cleft lip/palate.