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Bruker Paser Norvor, TIMS-DIA-NN 2.0, Mass Dynamics Knowledge Visualization

Bruker has released several new software tools for its timsTOF mass spectrometry platforms. The Paser Norvor software package enables de novo peptide sequencing and is aimed at immunopeptidomics applications. TheTIMS-DIA-NN 2.0 software package allows for processing of dia-PASEF data in a library-free approach and incorporates collisional cross-section data to improve accuracy. The Mass Dynamics Knowledge Visualization software provides visualization tools for exploring and analyzing proteomics datasets.

The Scan

Sick Newborns Selected for WGS With Automated Pipeline

Researchers successfully prioritized infants with potential Mendelian conditions for whole-genome sequencing or rapid whole-genome sequencing, as they report in Genome Medicine.

Acne-Linked Loci Found Through GWAS Meta-Analysis

Researchers in the European Journal of Human Genetics find new and known acne vulgaris risk loci with a genome-wide association study and meta-analysis, highlighting hair follicle- and metabolic disease-related genes.

Retina Cell Loss Reversed by Prime Editing in Mouse Model of Retinitis Pigmentosa

A team from China turns to prime editing to correct a retinitis pigmentosa-causing mutation in the PDE6b gene in a mouse model of the progressive photoreceptor loss condition in the Journal of Experimental Medicine.

CRISPR Screens Reveal Heart Attack-Linked Gene

Researchers in PLOS Genetics have used CRISPR screens to home in on variants associated with coronary artery disease that affect vascular endothelial function.