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Bruker NanoElute 2 nano-LC; MetaboScape and TASQ Software

Bruker has launched the NanoElute 2 nano-LC, and MetaboScape and TASQ 2023 software supporting fluxomics.

NanoElute 2 combines nano-LC chromatography with hardened high-pressure switching valves and finger-tight torque-limiting capillaries for leak-free zero dead volume connections, without the risk of overtightening or damaging capillaries, Bruker said. It also features an improved nano-LC pump design, and an intuitive and flexible user interface covering a broad range of applications from single-cell proteomics to plasma proteomics, the company said. NanoElute 2 now also supports the label-free ProteoCHIP for the CellenONE platform for high-sensitivity single cell proteomics.

The latest MetaboScape 2023 release provides streamlined collision cross section (CCS)-enabled metabolic profiling and annotation workflows covering 4D timsTOF data acquisition to high-confidence annotations for lipids and metabolites. New features include improved 4D peak detection and integration, accelerated processing, and smart merging of positive and negative ion data. Automated prediction of CCS values from chemical structures in spectral libraries leverages the accurate CCS values measured on the timsTOF.

In addition, MetaboScape 2023 now offers better means for data quality assessment in large-scale studies, while TASQ 2023 extends target screening and quantitation by CCS-enabled MOMA (minimization of metabolic adjustment) events. Finally, refinements to stable isotope labeling methods simplify large-scale labeling experiments, Bruker said.