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Allelica Ancestry-Specific Polygenic Risk Score Tests for Common Diseases

Allelica now offers ancestry-specific polygenic risk score (PRS) analysis for coronary artery disease, breast cancer, prostate cancer, type 2 diabetes, and Alzheimer's disease as lab-developed tests in partnership with Clinical Enterprise, a CLIA-certified, CAP-accredited laboratory located in Framingham, Massachusetts. These can be ordered as standalone single-PRS tests or as panels with multiple PRSs. Allelica plans to include more diseases across cardiology, oncology, and women's health in future offerings. DNA from patient saliva forms the input for a microarray genotyping analysis carried out by Clinical Enterprise. The output of that analysis feeds into Allelica's platform, which calculates ancestry-specific PRSs and generates clinical-grade reports via proprietary algorithms. Reports are also available as a white-label package, delivered to providers through a secure portal or through integration with electronic medical records.

The Scan

Genes Linked to White-Tailed Jackrabbits' Winter Coat Color Change

Climate change, the researchers noted in Science, may lead to camouflage mismatch and increase predation of white-tailed jackrabbits.

Adenine Base Editor Targets SCID Mutation in New Study

Researchers from the University of California, Los Angeles, report in Cell that adenine base editing was able to produce functional T lymphocytes in a model of severe combined immune deficiency.

Researchers Find Gene Affecting Alkaline Sensitivity in Plants

Researchers from the Chinese Academy of Science have found a locus affecting alkaline-salinity sensitivity, which could aid in efforts to improve crop productivity, as they report in Science.

International Team Proposes Checklist for Returning Genomic Research Results

Researchers in the European Journal of Human Genetics present a checklist to guide the return of genomic research results to study participants.