3Billon 3Cnet

3billion has introduced 3Cnet, a pathogenicity prediction tool that runs on recurrent neural networks. 3Cnet, which takes its name from the 3C analysis approach (conservation, clinical, and common), reviews protein sequences against known variants in public databases including ClinGen and the Genome Aggregation Database (gnomAD) to determine pathogenicity. The Korean firm claims that the software produced a top-one recall rate of 14.5 percent for pathogenic variants in 111 cases diagnosed based on American College of Medical Genetics and Genomics guidelines.