PerkinElmer Chemagic Prime
PerkinElmer has launched its Chemagic Prime automated nucleic acid isolation and assay setup instrument, which combines the company's Chemagic 360 instrument with the Janus automated liquid handling system. Researchers specializing in biobanking, genetics, and next-generation sequencing can use Chemagic Prime to streamline and automate high-quality DNA and RNA extraction for a wide range of human samples. Obtained nucleic acids can be used for a variety of downstream assays, such as NGS, genotyping, PCR, and MLPA, the firm said.
Chemagic Prime uses magnetized rods rather than magnetic plates to separate nucleic acids from solutions. This reduces the risk of contamination and isolates DNA and RNA that is more pure and intact. The instrument also incorporates additional liquid handling capabilities, which automates primary sample transfer, normalization, and setup of PCR assays and NGS libraries. Chemagic Prime can be paired with PerkinElmer's reagent kits for isolating nucleic acids from a variety of human samples, including whole blood, saliva, plasma, tissues, FFPE samples, and feces.
Agilent SureGuide Pooled CRISPR Libraries
Agilent Technologies has launched the first expansion of its SureGuide pooled CRISPR libraries for functional genomics, and is now offering pooled libraries for CRISPR activation and interference. The SureGuide CRISPR libraries are synthesized using Agilent's SurePrint DNA synthesis platform, which simultaneously prints billions of DNA bases. The new CRISPR a/i libraries incorporate gene targets developed by researchers at UCSF, Agilent said.
SureGuide CRISPR a/i libraries are offered in both Ready-to-Clone and Ready-to-Amplify formats. With Ready-to-Clone libraries, scientists can specify the sequence of each guide in the library or choose from validated predefined subsets of the genome, such as kinases or cancer genes. With Ready-to-Amplify libraries, investigators can fully design every aspect of the library, including the tracer sequence, allowing for the use of alternative delivery systems, guide structures, and cloning approaches, while targeting any organism of choice.
Desktop Genetics DESKGEN Series CRISPR Libraries
Desktop Genetics launched its DESKGEN Series CRISPR Libraries to support gene editing efforts in academic and biopharma settings. The series consists of six new CRISPR library products, each of which can be tailored to an investigator's list of genomic targets using any delivery method. Each product addresses a particular experimental application of the genome editing technology, the company said. Disrupt Libraries can be used to functionally knock out genes to reveal novel druggable targets and essential pathways; Tile Libraries saturate coding and non-coding regions to reveal genotype-phenotype relationships; SNP-In Libraries allow high-throughput insertion and deletion knockins across the genome; Interfere Libraries silence target gene expression with CRISPRi; Activate Libraries allow over-expression of target genes with CRISPRa; and Predict Libraries provide a unique scoring algorithm optimized for teams working on specific model cell lines or organisms, enabling other libraries to be designed more effectively.
Once the company receives a customer's list of targets, it designs the library using its proprietary DESKGEN AI and suite of bioinformatics pipelines. Once the designs are complete, the company manufactures the library in a variety of ready-to-use formats including plasmids, RNA, ribonucleoproteins, or as lentivirus, in either pooled or arrayed format.
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