Fluxion Biosciences Spotlight 59
Fluxion Biosciences has launched its Spotlight 59 Oncology Panel, a next-generation sequencing-based assay designed for liquid biopsy analyses. Used in conjunction with Fluxion's IsoFlux Liquid Biopsy System, the new panel is a complete sample-to-answer assay for high sensitivity mutation detection of solid tumor cancers from blood samples, the company said. In allowing ultra-sensitive variant detection from low input quantities of DNA, the panel is also potentially useful not only for liquid biopsy samples like circulating tumor cells or cell-free DNA, but also other challenging sample types such as FFPE.
For liquid biopsies, the panel's high sensitivity, driven by a bioinformatics method called ERASE-Seq, allows sensitivity to 0.1 percent allele frequency with no false positives, Fluxion said. The panel uses a 277-amplicon design based on Swift Biosciences Accel-Amplicon chemistry, covers hotspots in 59 clinically-relevant oncology-related genes, and generates multiplex libraries compatible with Illumina sequencing platforms, without the need for complicated molecular barcodes.
PerkinElmer NEXTflex Custom Amplicon Panels
PerkinElmer has launched several new NEXTflex Custom Amplicon panels that analyze BRCA1/2, CEBPA, HBOC-3, MEFV, TP53, and specific genes related to colon cancer, diabetes, and nephrotic syndrome. They can also detect somatic mutations in BRCA1/2 and TP53 loci. The panels offer a cost-effective solution for on-target reads with 100 percent coverage of targeted regions, the company said.
Personal Genome Diagnostics RNAcomplete
Personal Genome Diagnostics has launched RNAcomplete, a new testing service that allows researchers to co-extract total RNA and genomic DNA from a single tissue sample. The testing service uses RNA-seq to analyze gene transcripts corresponding to more than 34,000 genes and 84,000 transcript isoforms. It has been optimized for maximum performance using FFPE tissue and employs a macrodissection process for improved sensitivity and specificity, the company said.
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