Thermo Fisher Scientific Oncomine TCR Beta-SR Assay
Thermo Fisher Scientific has launched the Oncomine TCR Beta-SR Assay, a sequencing assay to characterize T-cell clonality in the tumor microenvironment. The test will interrogate the CDR3 region of the beta chain of the T-cell receptor, a region that is responsible for antigen recognition and helps to identify T-cell clones. The assay uses dual barcode indexing, which allows identification of low-frequency clones for potential tracking of minimal residual disease. It is optimized for formalin-fixed paraffin-embedded tissue, peripheral blood leukocytes, peripheral blood mononuclear cells, or cell-free DNA, and can work with either DNA or RNA as input.
Thermo Fisher Scientific Invitrogen TaqMan & SYBR Green Fast Advanced Cells-to-CT Kits
Thermo Fisher Scientific has launched Invitrogen TaqMan & SYBR Green Fast Advanced Cells-to-CT kits for real-time RT-PCR. The kits allow for a faster reverse transcriptase reaction and use a qPCR master mix system that is optimized to improve sensitivity to detect rare transcripts. They are designed for high-throughput gene expression analysis directly from cultured cells without RNA purification. The kits contain updated reverse transcription reagents for cDNA synthesis and faster TaqMan or SYBR Green master mixes for real-time PCR analysis.
Invitae Carrier Screen
Invitae has launched several genetic carrier screening products. The Invitae Comprehensive Carrier Screen uses next-generation sequencing to analyze 287 genes linked to serious genetic disorders and identifies more than 99 percent of disease-causing changes in most of the genes analyzed. In addition, the company offers a 46-gene test, called Invitae Broad Pan-Ethnic Carrier Screen, that assesses a smaller set of common disorders, and a test called Invitae Pan-Ethnic Carrier Screen that analyzes three genes associated with cystic fibrosis, spinal muscular atrophy, and fragile X syndrome. Both of the smaller panels can be supplemented with a customized set of genes from the large panel and with 13 genes not included in any pre-curated panel. The Invitae Carrier Screen replaces the GeneVu carrier screen from Good Start Genetics, which Invitae acquired last year.
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