Roche NGS Avenio Tumor Tissue Analysis Kits
Roche has launched three next-generation sequencing Avenio tumor tissue analysis kits for oncology research: the Avenio Tumor Tissue Targeted Kit, Expanded Kit, and Surveillance Kit. The new kits complement the company's NGS ctDNA kits. They use formalin-fixed paraffin-embedded tissue and have a workflow of five days. The Avenio Tumor Tissue Targeted Kit covers 17 genes to identify guideline-related biomarkers. The Avenio Tumor Tissue Expanded Kit is a 77-gene assay with both guideline-related and emerging biomarkers. The Avenio Tumor Tissue Surveillance Kit covers 197 genes and is intended for establishing a baseline for variants in longitudinal tumor burden monitoring.
Genoox Integrated Platform
Bionano Genomics and Genoox have launched the Genoox Integrated Platform for identification of structural variants. The companies said in April that they had partnered to develop a genome informatics workflow, which would integrate and annotate Bionano's structural variant calls with sequencing data within the Genoox platform.
Bionano said that the Saphyr system, combined with the firm's new DLS labeling chemistry and analysis tools, calls structural variants better than sequencing-based methods. By applying Genoox's variant classification technology to align short read sequence data to its structural variant calls, the high sensitivity of Bionano calls would be combined with the base-pair precision of NGS. The Genoox Integrated Platform further automatically validates and confirms structural variant calls, in addition to integrating and annotating structural variants with smaller sequence variants in the same genome, the firms said. The tool provides sensitive, accurate detection of structural variation and genetic mutations, helping to speed genetic diagnosis.
The new platform combines raw NGS read data with Bionano-based structural variant calls from a single patient. Researchers then use Bionano's structural variant data to guide the alignment of NGS reads. Detected structural variants, copy number variants, indels, and single nucleotide variants are then annotated by aggregating data from multiple clinical and population frequency databases, and automated AI-based classification according to ACMG guidelines, the companies said. The platform then generates a customized clinical report on all variants, including Bionano-only and NGS-only calls. Genoox and Bionano will co-sell and co-market the integrated platform.
Ubiquitome Liberty16
Ubiquitome has launched the Liberty16, a quantitative PCR system designed for personal and mobile DNA quantitation and testing. The Liberty16 has dimensions of 21.2 cm long (closed) by 11 cm wide by 11.5 cm tall, and weighs about 3.2 kg. It runs on a light, small, and rechargeable lithium battery for two to three hours of cord-free run time. The instrument can be Bluetooth paired with an iPhone app for laptop-free standalone operation. It is compatible with standard consumables and chemistries including Taqman and SYBR, and uses the industry-standard eight-strip PCR tube and cap format.
The instrument starts at $1,500 and Ubiquitome is taking pre-orders from researchers on a 'first-come, first-served" basis.
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