Cellecta DriverMap RNA-Seq Panels, Analysis Software
Cellecta has launched five DriverMap Predesigned RNA-Seq panels, including the Human Cell Marker Panel, Human Hallmark Signatures Panel, Human LINCSx Panel, Human Pan-Cancer Pathway Panel, and the Human Transcription Factor Signature Panel. Each panel measures expression levels of over 1,200 curated essential genes selected from publications, open access databases, and other resources. The panels use the same multiplex RT-PCR followed by next-generation sequencing approach as the firm's DriverMap Expression Profiling assay, which measures expression levels of all protein-coding human genes.
The kits include a complete set of gene-specific and PCR-NGS primers, buffers, spiked-in EERC and positive control RNAs, as well as all necessary reagents required to profile 96 samples and prepare them for digital expression profiling on a Illumina sequencing platform also come with genome alignment software that provides differential expression data in an excel spreadsheet format.
Indigo Biosciences Gene Expression Assay Kit
Indigo has launched a gene expression assay kit featuring optimized "Upcyte" hepatocytes, which are human donor-derived liver cells established by Upcyte Technologies. The kit provides optimized reagents for culturing and treatment of Upcyte hepatocytes to examine drug-induced changes in the expression of seven clinically relevant cytochrome P450 enzymes. According to the firm, the hepatocytes combine the advantages of primary hepatocytes with the added practical advantage of having access to the same donor cells for use in iterative, large-scale testing over extended periods.
Expedeon MagniPhi & QualiPhi DNA Polymerases
Expedeon has launched two high-fidelity polymerases, MagniPhi DNA Polymerase and QualiPhi DNA Polymerase. Expedeon offers the products in both 25- and 100-reaction kits, which contain DNA polymerases and their associated reaction buffers. The firm said MagniPhi — a wild-type form of the Phi29 DNA polymerase — is ideal for isothermal DNA amplification. According to Expedeon, MagniPhi's fidelity of synthesis produces up to 100 times fewer errors than Taq polymerase, while the amplification reaction yields more whole-genome amplification compared to normal PCR-based WGA techniques.
Expedeon's QualiPhi — a chimeric form of the Phi29 DNA Polymerase — has been engineered for enhanced sensitivity and efficiency while preserving the high processivity of the wild type Phi29. According to the firm, the polymerase's higher sensitivity allows improved amplification of DNA from low to high input concentrations and higher yields than the wild-type polymerase.
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