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New Products: Oxford Nanopore, Bio-Rad, MGI, More

Oxford Nanopore Technologies R10.3 Nanopore Chemistry

Oxford Nanopore Technologies has released flow cells using the R10.3 nanopore chemistry. It is currently available for MinIon and PromethIon sequencers and will be available for Flongle flow cells at a later time. The R10.3 chemistry, which is suitable for use with the LSK109 kit at launch, improves on the R10. Like the R10, it uses a pore with a longer barrel and a dual reader head, which improves resolution of homopolymers and consensus accuracy. Compared to the R10, it has increased throughput and capture, is compatible with PromethIon flow cells, has input amounts closer to the R9.4.1 chemistry, and has improved raw accuracy to match the R9.4.1 and to support enhanced variant calling.

Bio-Rad Laboratories SEQuoia

Bio-Rad Laboratories announced the launch of the SEQuoia Complete Stranded RNA Library Prep Kit for RNA-Seq library preparation. The kit uses SEQzyme, an enzyme that couples cDNA synthesis with adapter addition in a continuous synthesis reaction. It is compatible with a broad range of sample inputs and allows capture of the complete transcriptome, including short and long RNAs, in a single library prep. The kit generates cDNA libraries suitable for strand-specific next-generation sequencing on Illumina sequencers in less than four hours. It also includes access to the integrated SeqSense analysis solution to process and quality control sequencing data for all RNA biotypes in the library within a single analysis pipeline.

MGI One Million Genomes Total Solution

MGI has released One Million Genomes Total Solution, a software and hardware solution for large-scale population genome sequencing projects that combines sample preparation, high-throughput sequencing, and data analysis. The package consists of a whole-blood pretreatment system that has an annual output of up to 600,000 samples, an automated library preparation system with an annual output of up to 500,000 samples, and MGI's ultra-high-throughput DNBSEQ-T7 sequencer that can sequence 600,000 to 800,000 samples per year. It also includes a data processing platform with computing and storage capabilities that can analyze 100,000 to 1 million samples per year. In addition, the solution integrates a laboratory management system. It uses blockchain technology for data security and privacy.

For more new products and services, please visit the New Products page on our website.

The Scan

Suicidal Ideation-Linked Loci Identified Using Million Veteran Program Data

Researchers in PLOS Genetics identify risk variants within and across ancestry groups with a genome-wide association study involving veterans with or without a history of suicidal ideation.

Algorithm Teases Out Genetic Ancestry in Individuals at Biobank Scale

Researchers develop an algorithm known as Rye to tease apart ancestry fractions in admixed individuals at a biobank-scale, applying it to 488,221 UK Biobank participants in Nucleic Acids Research.

Multi-Ancestry Analysis Highlights Comparable Common Variants at Complex Trait-Linked Loci

Researchers in Nature Genetics examine common variants implicated in more than three dozen conditions, estimating genetic effect similarities across ancestry tracts in admixed individuals.

Sick Newborns Selected for WGS With Automated Pipeline

Researchers successfully prioritized infants with potential Mendelian conditions for whole-genome sequencing or rapid whole-genome sequencing, as they report in Genome Medicine.