Oxford Nanopore Technologies R10.3 Nanopore Chemistry
Oxford Nanopore Technologies has released flow cells using the R10.3 nanopore chemistry. It is currently available for MinIon and PromethIon sequencers and will be available for Flongle flow cells at a later time. The R10.3 chemistry, which is suitable for use with the LSK109 kit at launch, improves on the R10. Like the R10, it uses a pore with a longer barrel and a dual reader head, which improves resolution of homopolymers and consensus accuracy. Compared to the R10, it has increased throughput and capture, is compatible with PromethIon flow cells, has input amounts closer to the R9.4.1 chemistry, and has improved raw accuracy to match the R9.4.1 and to support enhanced variant calling.
Bio-Rad Laboratories SEQuoia
Bio-Rad Laboratories announced the launch of the SEQuoia Complete Stranded RNA Library Prep Kit for RNA-Seq library preparation. The kit uses SEQzyme, an enzyme that couples cDNA synthesis with adapter addition in a continuous synthesis reaction. It is compatible with a broad range of sample inputs and allows capture of the complete transcriptome, including short and long RNAs, in a single library prep. The kit generates cDNA libraries suitable for strand-specific next-generation sequencing on Illumina sequencers in less than four hours. It also includes access to the integrated SeqSense analysis solution to process and quality control sequencing data for all RNA biotypes in the library within a single analysis pipeline.
MGI One Million Genomes Total Solution
MGI has released One Million Genomes Total Solution, a software and hardware solution for large-scale population genome sequencing projects that combines sample preparation, high-throughput sequencing, and data analysis. The package consists of a whole-blood pretreatment system that has an annual output of up to 600,000 samples, an automated library preparation system with an annual output of up to 500,000 samples, and MGI's ultra-high-throughput DNBSEQ-T7 sequencer that can sequence 600,000 to 800,000 samples per year. It also includes a data processing platform with computing and storage capabilities that can analyze 100,000 to 1 million samples per year. In addition, the solution integrates a laboratory management system. It uses blockchain technology for data security and privacy.
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