New FISH Approach Quantifies Allele-specific Expression in Cell Populations, Single Cells | GenomeWeb

NEW YORK (GenomeWeb News) – Using a revamped fluorescent in situ hybridization-based approach, researchers from the University of Pennsylvania were able to detect and quantify single-nucleotide variants in RNA transcripts in both populations of cells and in single cells. As they reported in Nature Methods yesterday, they also used their technique to distinguish between transcripts from maternally and paternally inherited chromosomes.

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In Nucleic Acids Research this week: personal genome approach to RNA-seq read alignment, hematopoietic Systems Biology Repository, and more.

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