NEW YORK (GenomeWeb News) – Using a revamped fluorescent in situ hybridization-based approach, researchers from the University of Pennsylvania were able to detect and quantify single-nucleotide variants in RNA transcripts in both populations of cells and in single cells. As they reported in Nature Methods yesterday, they also used their technique to distinguish between transcripts from maternally and paternally inherited chromosomes.

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In PLOS this week: Uncovering variants associated with diabetes-related kidney disease, a sequencing study of hepatitis E viruses circulating in Cambodia, and more.

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