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New Change Reported

A new SARS-CoV-2 gene variant has been identified in the UK, Reuters reports.

It adds that UK Health Secretary Matt Hancock has said the variant has been identified in more than 1,000 cases, particularly in southern England. 

The Guardian reports that Hancock told Parliament that the variant was identified through genomic analyses and could be linked to increased spread in the region, but that there is no evidence that the variant is associated with more severe disease. "But it shows we've got to be vigilant and follow the rules and everyone needs to take personal responsibility not to spread this virus," he added, according to the Guardian. BBC News adds London and some nearby areas are moving to tier three restrictions — the highest level — on Wednesday, which entails restaurants and pubs closing or shifting to to-go or delivery orders and places limits on indoor and outdoor gatherings.

The World Health Organization's Mike Ryan said during a briefing that the agency was aware of the variant, Reuters reports. "Authorities are looking at its significance," he added. "We have seen many variants, this virus evolves and changes over time."

In September, for instance, researchers at Houston Methodist Hospital found that a strain with a Gly614 change outspread other strains.

The Scan

Suicidal Ideation-Linked Loci Identified Using Million Veteran Program Data

Researchers in PLOS Genetics identify risk variants within and across ancestry groups with a genome-wide association study involving veterans with or without a history of suicidal ideation.

Algorithm Teases Out Genetic Ancestry in Individuals at Biobank Scale

Researchers develop an algorithm known as Rye to tease apart ancestry fractions in admixed individuals at a biobank-scale, applying it to 488,221 UK Biobank participants in Nucleic Acids Research.

Multi-Ancestry Analysis Highlights Comparable Common Variants at Complex Trait-Linked Loci

Researchers in Nature Genetics examine common variants implicated in more than three dozen conditions, estimating genetic effect similarities across ancestry tracts in admixed individuals.

Sick Newborns Selected for WGS With Automated Pipeline

Researchers successfully prioritized infants with potential Mendelian conditions for whole-genome sequencing or rapid whole-genome sequencing, as they report in Genome Medicine.