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A New Branch

Researchers present the mitochondrial genome from the 2,330-year-old remains of man who lived in Southern Africa in Genome Biology and Evolution. Archaeological evidence and bone analysis indicated that the man was a marine forager and lived in the region prior to the arrival of migrating pastoralists.

The Garvan Institute of Medical Research's Vanessa Hayes and her colleagues isolated DNA from a tooth and a rib from the skeleton and sequenced and assembled the mitochondrial DNA.

By comparing the mtDNA from this 2,330-year-old man to some 525 published complete genomes, Hayes and her colleagues found that his mtDNA forms a new, early derived maternal lineage — L0d2c1c —that is, unlike its sister L0d2c1a and L0d2c1b clades, closely related to contemporary indigenous San-speakers

"From [mitochondrial] Eve, this [individual] comes from the earliest branch, which diverged around 150,000 to 170,000 years ago," Hayes tells the Sydney Morning Herald.

She and her colleagues note in their paper that additional sequencing of ancient people from southern Africa "is likely to expose additional unclassified human genome diversity.

The Scan

NFTs for Genome Sharing

Nature News writes that non-fungible tokens could be a way for people to profit from sharing genomic data.

Wastewater Warning System

Time magazine writes that cities and college campuses are monitoring sewage for SARS-CoV-2, an approach officials hope lasts beyond COVID-19.

Networks to Boost Surveillance

Scientific American writes that new organizations and networks aim to improve the ability of developing countries to conduct SARS-CoV-2 genomic surveillance.

Genome Biology Papers on Gastric Cancer Epimutations, BUTTERFLY, GUNC Tool

In Genome Biology this week: recurrent epigenetic mutations in gastric cancer, correction tool for unique molecular identifier-based assays, and more.