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NINDS Offers $8M for Parkinson's Centers

By a GenomeWeb staff reporter

NEW YORK (GenomeWeb News) – The National Institute of Neurological Disorders and Stroke plans to spend up to $8 million next year to start two centers that will provide support and services for its planned Parkinson's Disease Biomarkers Identification Network (PD-BIN), a new multisite program to identify markers for the risk, onset, and progression of PD.

These grants will provide up to $4 million each for the establishment of a Clinical Coordinating Center (CCC) and a Data Coordinating Center (DCC), or $8 million to an entity that would house both centers.

The CCC will be responsible for overseeing all aspects of subject recruitment and specimen collection for the program, including managing multiple clinical sites, enrollment of a core cohort of newly diagnosed PD patients, and collection of all clinical and biological data.

The DCC will provide all data management needs for the network, including standardized acquisition, quality control, dissemination, and public accessibility.

The data and biospecimens these centers generate will be used to create a publicly available resource for biomarker validation and discovery that will be available to investigators inside and outside of the PD-BIN. The centers will need to be able to accommodate projects that investigate biomarkers for PD based on a wide range of technologies.

The core biospecimens may come from collected DNA, serum, plasma, whole blood, and urine.

The Scan

For Better Odds

Bloomberg reports that a child has been born following polygenic risk score screening as an embryo.

Booster Decision Expected

The New York Times reports the US Food and Drug Administration is expected to authorize a booster dose of the Pfizer-BioNTech SARS-CoV-2 vaccine this week for individuals over 65 or at high risk.

Snipping HIV Out

The Philadelphia Inquirer reports Temple University researchers are to test a gene-editing approach for treating HIV.

PLOS Papers on Cancer Risk Scores, Typhoid Fever in Colombia, Streptococcus Protection

In PLOS this week: application of cancer polygenic risk scores across ancestries, genetic diversity of typhoid fever-causing Salmonella, and more.