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NIH to Fund DNA Data, Sample Storage

By a GenomeWeb Staff Reporter

NEW YORK (GenomeWeb News) – In an effort to advance genetic data and sample storage capabilities, the National Institutes of Health will fund a new DNA repository for alcoholism research and an Alzheimer's Disease Genetics Data Warehouse, the agency said Friday.

One grant from the National Institute on Alcohol Abuse and Alcoholism will fund development of support infrastructure for a DNA storage facility with up to $3 million next year. This facility will receive and extract DNA, perform genotyping for ancestry markers, and store and distribute to sequencing labs samples collected in the NIAAA National Epidemiologic Survey on Alcohol and Related Conditions III program.

The NIAAA DNA Repository will receive around 43,000 samples from the epidemiology survey and will perform extensive DNA extraction and, in some cases, amplification services. This grant winner also will conduct pre-testing requirements for DNA that it supplies for sequencing, conduct sample selection, enter the sample and quality control data in a lab information management system, and provide security, privacy, and confidentiality of all genetic data.

Another grant from the National Institute on Aging plans to provide up to $500,000 next year to institutions or organizations to start a resource that will support the Alzheimer's research community by housing data from and providing data for a range of genome sequencing research projects.

The NIA grant will be used to create a resource for AD researchers that will provide a repository for collecting and sharing of data from genome-wide association studies, next-gen sequencing, targeted genome sequencing, and genomic analysis research. The data stored at this site could include genetic and phenotypic data that is relevant to genetic analysis, such as clinical and neuropathology information. This Data Warehouse also should be able to accept and link to associated data from other AD-related databases, and it should be able to link with other genetic research resources provided by the National Center for Biotechnology Information.

The warehouse also will keep updated lists of important resources available to the research community, and it will develop a web-based data entry system that can be accessed by qualified investigators for use in their research. It will house, archive, process, and distribute genetic data, and publicly display research results, and genetic, gene expression, and epigenomic data related to AD research should be available at the level of specific genes.

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