Skip to main content
Premium Trial:

Request an Annual Quote

Alzheimer's Disease Neuroimaging Initiative Enters Third Phase

NEW YORK (GenomeWeb) – The National Institutes of Health announced today the launch of the third phase of the Alzheimer's Disease Neuroimaging Initiative (ADNI), which will include the use of new brain imaging technologies and the recruitment of new volunteers for the program.

The ADNI was launched 12 years ago to conduct a longitudinal, prospective, naturalistic study of normal cognitive aging, mild cognitive impairment, and early Alzheimer's disease in order to develop neuroimaging technologies and biomarkers for the onset and progression of the disorders. Individuals participating in the study complete various imaging and clinical assessments, and are followed and reassessed over time.

In its first two phases, the ADNI enrolled roughly 800 volunteers and included examinations using MRIs and functional MRIs, diffusion tensor imaging, and AV45-, FDG-, and PIB-PET scans, in addition to blood, cerebrospinal fluid, and DNA analyses. In the newest phase, the initiative will include the use of tracers that image tau protein tangles — a known indicator of Alzheimer's disease — in vivo, the NIH said.

The third phase of the ADNI — called ADNI3 — will also add the use of new measurements of cognitive ability and track cognitive changes in volunteers online via the Brain Health Registry. It is expected to enroll an additional 1,200 volunteers across the US and Canada.

"ADNI3 will move the bar higher still in this collaborative effort to gain a clear understanding of the subtle Alzheimer's-related brain changes in volunteers, long before symptoms appear, and the biological changes that mark its progression," National Institute on Aging Director Richard Hodes said in a statement. "These insights are vital to researchers and clinicians working worldwide in their selection of clinical trial volunteers and the testing of promising interventions."

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.