Neurological & Psychological Disorders News on research and diagnostic developments in neuroscience. Polygenic Risk Score Addition Does Not Improve Models Predicting Schizophrenia Prognosis The findings highlight the need for polygenic risk scores to not only be predictive but also provide additional information that cannot be captured elsewhere more easily. FinnGen Project's Role in Epilepsy, Drug Adherence Studies Showcased at ESHG Both studies relied on data collected via the FinnGen project, an international effort to collect genotype and health registry data on 500,000 people in Finland by 2023. Children With Autism May Have Underdeveloped Gut Microbiomes, Metagenomic Analysis Finds The researchers are now developing a PCR-based diagnostic tool to evaluate the markers they found in a larger, independent cohort and across different populations. Gene-Disrupting Ultra-Rare Variants More Common in Children With Autism Spectrum Disorder The study's findings further support a multi-hit model for autism risk, especially among cases where autism runs in the family. Multi-Ethnic Migraine GWAS Uncovers Risk Loci Specific to Sex, Ancestry Investigators analyzed genetic data for more than half a million individuals, detecting susceptibility sites specific to women or European individuals. Jun 28, 2021 Obsessive Compulsive Disorder Exome Analysis Uncovers Contributions From Rare Coding Variants Jun 23, 2021 Infinity BiologiX to Offer Cytox Alzheimer's Disease Genetic Risk Test in US Jun 17, 2021 GWAS Reveals New Loci Linked to Brain White Matter Microstructure Jun 17, 2021 New ALS Risk Gene Suggests Role for Apoptosis Jun 15, 2021 Autism Sharing Initiative Brings Federated Data Model to Research, Clinical Care Premium Jun 15, 2021 Study Explores Usefulness of NfL as Biomarker Across Range of Neurological Conditions Premium Jun 14, 2021 Alzheimer's Disease Phosphoproteomics Study Uncovers Signaling Abnormalities Jun 10, 2021 Alzheimer's Disease Meta-Analysis Identifies Novel Differentially Methylated Loci May 27, 2021 Large-Scale Depression Genetic Study Uncovers Additional Risk Loci, Ties to Potential Drugs May 26, 2021 23andMe Begins Reporting PGx Variants With Drug Info Under Recent FDA Clearance Premium May 21, 2021 NIH, Genomics England Launch Large-Scale Human Genome Sequencing Studies Using Nanopore Technology May 21, 2021 European Project to Harness Biobanks, EHRs to Develop Precision Psychiatry Tools Premium May 20, 2021 Rabid-Seq Method Offers NGS-Based View of Cellular Interactions in the Brain Premium May 19, 2021 Analysis Uncovers Hundreds of Autism-Linked Genes Using Evolution-Informed Approach May 17, 2021 Bipolar Disorder GWAS Meta-Analysis Points to Potential Treatment Targets May 6, 2021 Parkinson's Disease Progression Linked to Five Variants in Genome-Wide Survival Study May 5, 2021 Myriad Genetics Projects Return to Profitability by Year End, Details Long-Term Growth Plan Premium May 3, 2021 InformedDNA Partners With Gene Therapy Firm Passage Bio on Dementia Genetic Testing Apr 30, 2021 GWAS-Methylation Integration Could Help Identify Drug Repurposing Candidates for MS Premium Apr 29, 2021 Valted Seq Lands Exclusive Rights to Evaluate Johns Hopkins Neurodegenerative Disease Dx Assays Load More Breaking News Ancient DNA Analysis Highlights Three Ancestral Populations in Japan FDA Warns of Potential False Positives With Abbott SARS-CoV-2 Molecular Tests New Products Posted to GenomeWeb: Oxford Nanopore, Beckman Coulter, Thermo Fisher Scientific, More People in the News: New Appointments at Sema4, NHGRI, Dante Labs, Ancestry, More Thermo Fisher Scientific Expects 12 Percent Revenue Growth in 2022 In Brief This Week: Myriad Genetics, Danaher, Co-Diagnostics, and More The Scan For Those Thick Tiger Stripes Tigers in India with thick stripes harbor a genetic change, as Gizmodo reports. High GABA Tomatoes The Japan News reports that genome-edited tomatoes with higher GABA levels are now for sale in Japan. Approach for Inclusivity and Diversity A National Human Genome Research Institute team calls for the field to "adopt diversity as an ethos." Science Papers on Tumors Immune System Evasion; Drivers of Genomic Instability, Inflammation In Science this week: study of how tumors evade the adaptive immune system, and more.