Musculoskeletal News on in vitro diagnostics for musculoskeletal disorders. Osteoarthritis GWAS Leads to Key Genes, Treatment Targets With a genome-wide association study and functional follow-up analyses, investigators saw 100 osteoarthritis-related loci including variants in potentially targetable genes and pathways. Facial Phenotyping of Siblings Helps Identify Genetic Loci Affecting Face Shape Many but not all of the loci identified had previously been tied to embryonic facial development or the abnormal development of facial features. Genetic Study Explains Link Between Osteoporosis Drug, Cardiovascular Risk The findings underscore the value of carrying out large-scale human genetic analyses as part of drug target identification and validation efforts. Personalis, Sarepta Therapeutics Exploring Immune Response to Precision Genetic Therapeutics The companies are applying Personalis' technology to explore immune response to genetic therapeutics in Sarepta's pipeline. Jackson Lab, Shriners Hospitals to Study Genetics of Pediatric Orthopedic Disorders The alliance comes a few months after Shriners Hospitals established a new genomics institute in Tampa, Florida in partnership with Genome Medical. Dec 10, 2019 Invitae, BioMarin Partner on Access to Genetic Testing for Skeletal Dysplasias Oct 14, 2019 CureDuchenne, UC Irvine, RUCDR Partner on Muscular Dystrophy Biobank Oct 10, 2019 RNA-Seq Data Helps Focus Search for Rare Variants Oct 8, 2019 FDA Awards $2.4M to Vanderbilt Researcher for Duchenne Muscular Dystrophy Biomarker Study Jul 17, 2019 Multiple Sclerosis Single-Cell Transcriptome Study Highlights Affected Cell Types, Brain Regions May 1, 2019 Cleft Palate Study Shows Transcription Factor, Enhancer Roles in Related Developmental Processes Oct 19, 2018 Epilepsy, Developmental Disorders Linked to De Novo Mutations in Calcium Channel Subunit Oct 15, 2018 Sanofi Genzyme, PerkinElmer Launch Free Dx Program for Patients With Lysosomal Storage Disorders Aug 30, 2018 Bone Mineral Density at Forefront in Genetic Fracture Risk Meta-Analysis Jul 26, 2018 Bone Density GWAS Leads to New Loci, Osteoporosis Risk Score Jun 29, 2018 TRAF7 Mutations Implicated in Rare Multisystem Disorder Apr 27, 2018 Invitae, Biogen Partner on Free Spinal Muscular Atrophy Genetic Testing Program Breaking News SARS-CoV-2 Genome Analysis Reveals Fitness-Enhancing Mutations Startup Incubator IndieBio, GP-Write Launch Initiative to Fund Genome Engineering Firms Precipio Receives CE-IVD Mark for Hematologic Cancer Panels Illumina Adds CDx Indication to European TruSight Oncology Test for NTRK Gene Fusion Detection BioMérieux Gets Health Canada Approval for Updated BioFire Blood Culture ID Panel CareDx Receives CE Mark for Hematopoietic Cell Transplantation Testing Kit, Analysis Software The Scan Taking Stock of the Stockpile The US and European countries are evaluating their smallpox vaccine stockpiles as the number of monkeypox cases increases, the Washington Post reports. Vitamin D From Tomatoes According to Reuters, researchers in the UK have gene-edited tomatoes so their fruit contains vitamin D. Cause Not Yet Spotted NPR reports that a new study was unable to find a cause for persistent long COVID symptoms. PNAS Papers on Central African Hunter-Gatherers, Myopia Development, Ancient Microtia Allele In PNAS this week: population patterns among Central African hunter gatherers, effect of myopia-linked gene variant, and more.