Skip to main content
Premium Trial:

Request an Annual Quote

Quadrant Biosciences Wins $2.3M NIH Grant to Develop Saliva Test for Concussion

NEW YORK — Quadrant Biosciences said on Monday that it has received a $2.3 million grant from the National Institutes of Health to develop its saliva-based microRNA diagnostic test for concussions in children and adolescents.

Syracuse, New York-based Quadrant has been working with researchers from Penn State University and SUNY Upstate Medical University on saliva-based biomarkers of various neurological conditions. In 2018, they published data linking saliva concentrations of multiple miRNAs with concussion duration and symptoms in children.

With the newly awarded Fast-Track Phase I/II Small Business Technology Transfer grant, Quadrant aims to develop a rapid method for quantifying these biomarkers for potential point-of-care use. It also plans to validate a diagnostic algorithm designed to distinguish mild traumatic brain injury (mTBI) from medical conditions with overlapping symptoms, such as chronic headaches and exercise-related fatigue.

The research will be conducted in a study of 2,500 adolescents and young adults with either a formal diagnosis of an mTBI or an overlapping medical condition, in collaboration with SUNY Upstate, SUNY Buffalo, Arkansas Children's, Children's Hospital of Michigan, and Penn State Medical Centers.

The Scan

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.

Study Looks at Parent Uncertainties After Children's Severe Combined Immunodeficiency Diagnoses

A qualitative study in EJHG looks at personal, practical, scientific, and existential uncertainties in parents as their children go through SCID diagnoses, treatment, and post-treatment stages.

Antimicrobial Resistance Study Highlights Key Protein Domains

By screening diverse versions of an outer membrane porin protein in Vibrio cholerae, researchers in PLOS Genetics flagged protein domain regions influencing antimicrobial resistance.

Latent HIV Found in White Blood Cells of Individuals on Long-Term Treatments

Researchers in Nature Microbiology find HIV genetic material in monocyte white blood cells and in macrophages that differentiated from them in individuals on HIV-suppressive treatment.