NEW YORK (GenomeWeb) – The perfect drug molecule, according to Pfizer's Jean-Claude Marshall, is one that is right on target, has no off-target effects, and is highly bioavailable. Importantly, it is metabolized by a range of enzymes but not dependent on those really buggy ones, like CYP2D6, that can be variable.
"No drug is going to be that. We know that right up front," Marshall, director of Pfizer's Clinical Pharmacogenomics Lab, told GenomeWeb last week. "It's just our goal to attain that."