Skip to main content
Premium Trial:

Request an Annual Quote

Agilent's Opdivo CDx Gets Expanded CE Mark in Europe

NEW YORK (GenomeWeb) – Agilent Technologies announced today that its Dako PD-L1 IHC 28-8 pharmDx test, a companion diagnostic for Bristol-Myers Squibb's cancer drug Opdivo (nivolumab), has has received an expanded CE mark for use in Europe.

According to the company, the test can now be used in identifying patients with urothelial cancer who are most likely to benefit from Opdivo therapy. The test is already marketed in Europe for tumor cell PD-L1 expression for non-squamous non-small-cell lung cancer (ns-NSCLC), melanoma, and squamous cell carcinoma of the head and neck. 

The test is also approved in the US a complementary diagnostic for Opdivo for ns-NSCLC and for assessing the magnitude of benefit melanoma patients might derive from the drug.

The Scan

Study Links Genetic Risk for ADHD With Alzheimer's Disease

A higher polygenic risk score for attention-deficit/hyperactivity disorder is also linked to cognitive decline and Alzheimer's disease, a new study in Molecular Psychiatry finds.

Study Offers Insights Into Role of Structural Variants in Cancer

A new study in Nature using cell lines shows that structural variants can enable oncogene activation.

Computer Model Uses Genetics, Health Data to Predict Mental Disorders

A new model in JAMA Psychiatry finds combining genetic and health record data can predict a mental disorder diagnosis before one is made clinically.

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.