NEW YORK (GenomeWeb) – Researchers from Alnylam Pharmaceuticals this week published a study describing the company's development of GalNAc conjugates, which Alnylam is using with all of its newest drug candidates to deliver siRNAs into the liver.

The technology is based on N-acetylgalactosamine ligands, which have a high affinity for the asialoglycoprotein (ASGPR) receptors expressed on the surface of hepatocytes. While the concept of using these ligands for drug delivery in not new, doing so has been a challenge.

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