NEW YORK (GenomeWeb) – Alnylam Pharmaceuticals this week announced that it has initiated two new clinical trials, a Phase III study of its TTR-mediated amyloidosis (ATTR) drug revusiran and a Phase I study of its hypercholesterolemia therapy ALN-PCSsc.

Both drugs are administered subcutaneously using Alnylam's GalNAc conjugates.

ATTR is a condition characterized by the accumulation of amyloid deposits in tissues due to mutations in the TTR gene. Revusiran is designed to silence both mutant and wild-type TTR.

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