NEW YORK (GenomeWeb) – A team from the US and Canada has tracked brain gene expression dynamics in individuals over the span of a day and across different age groups, demonstrating that circadian patterns in the brain may shift with age.

Using array-based gene expression profiling, the researchers assessed two prefrontal cortex samples per person in almost 150 deceased individuals. By combining information on each individual's age with his or her time of death, they were able to detect age-related differences in the expression of circadian clock-related genes.

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